M-CSF

Item no.	RLT-R20-050S
Manufacturer	ReliaTech
Amount	2ug
Category	Peptides & Proteins Recombinant Proteins
Type	Cytokines and Growth Factors
Format	Lyophilized
Specific against	Mouse, Rat
Host	E.coli
ECLASS 10.1	42030690
ECLASS 11.0	42030690
UNSPSC	12352202
Alias	Csf1
Available
NCBI Gene ID	78965
Uniprot	Q6GMN4
Biological Activity	The ED50 was determined by the dose-dependent stimulation of the proliferation of murine M-NFS-60 cells is = 5.0 ng/ml, corresponding to a specific activity of = 2 x 105 units/mg.
Description	M-CSF is a potent hematopoietic factor produced by a variety of cells including lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts and osteoblasts. It is a key regulator of cellular proliferation, differentiation, and survival of blood monocytes, tissue macrophages and their progenitor cells. M-CSF has been shown to play important roles in modulating dermal thickness, and male and female fertility. M-CSF is clinically used in the treatment of infection, malignancies and atherosclerosis. It facilitates hematopoietic recovery after bone marrow transplantation. The human is reactive in murine systems, but the murine molecule exhibits no activity on human cells. Recombinant rat M-CSF is a 18.1 kDa homodimeric protein containing two 155 amino acid polypeptide subunits.
Endotoxin Levels	< 0.1 ng/µg of protein (<1EU/µg)
Length [aa]	155
Molecular Weight	18.1 kDa
mRNA RefSeq	NM_023981
Protein RefSeq	NP_076471.3
Protein Sequence	MEVSEHCSHM IGNGHLQILQ QLIDSQMETA CLIEYKFVDQ EQLDDPVCYL KKAFVLVQVI IEETMRFKDN TPNANATERL QELSMKLNSC FIKDYKEQNE ACVQTYKESP LRLLEKIKNF FNETKNFLEK DWNIFSKNCN DSLAKCSSRD VVTKP
Purity Confirmation	> 98% by SDS-PAGE & HPLC analyses
Synonyms	Csf1
Uniprot ID	Q6GMN4

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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