Item no. |
RLT-100-435S |
Manufacturer |
ReliaTech
|
Amount |
50ug |
Category |
|
Type |
Cytokines and Growth Factors |
Format |
Lyophilized |
Specific against |
Human |
Host |
CHO cells |
ECLASS 10.1 |
42030690 |
ECLASS 11.0 |
42030690 |
UNSPSC |
12352202 |
Alias |
Plasma protease C1, C1inh, C1 Esterase Protein, C1-inhibiting factor, Serpin G1 |
Available |
|
NCBI Gene ID |
710 |
Uniprot |
P05155 |
Biological Activity |
Measured by its ability to inhibit recombinant human complement component C1a cleavage of a colorimetric peptide substrate, N Carbobenzyloxy-Lys-ThioBenzyl ester (Z-K-SBzl). The expected IC50 is = 2.6 nM. |
Description |
C1 Inhibitor is a member of the serpin family of structurally related proteins, and is the primary regulator of the immune complement system. C1Inhibitor is a protease inhibitor that functions to inhibit the complement system in order to prevent over-activation or spontaneous activation. Inhibition is achieved by binding to and irreversibly inhibiting the C1r and C1s proteases of the C1 complex, which has the effect of shutting down all subsequent downstream events in the complement activation cascade. C1inhibitor can also inhibit various other proteases, including Kallikrein, Factor XIa, and Factor XIIa. Deficiencies in C1inhibitor are the primary cause of hereditary angioedema (HAE, hereditary angioneurotic edema), a disease characterized by edema in the respiratory and gastrointestinal tracts. In certain clinical situations, the direct administration of C1inhibitor can be used to treat HAE and certain other conditions. Recombinant Human C1 Inhibitor is a highly glycosylated glycoprotein containing 445 amino acid residues (49.4kDa), corresponding to amino acids 56 – 500 of the C1 inhibitor precursor, and is fully functional in its ability to inhibit the C1 complex. Glycosylated C1 Inhibitor migrates at an apparent molecular weight of approximately 80-90 kDa by SDS PAGE analysis under reducing conditions. |
Endotoxin Levels |
< 0.1 ng/µg of protein (<1EU/µg) |
Length [aa] |
445 |
Molecular Weight |
49.4 kDa |
mRNA RefSeq |
NM_000062.2 |
Protein RefSeq |
NP_000053.2 |
Protein Sequence |
VEPILEVSSL PTTNSTTNSA TKITANTTDE PTTQPTTEPT TQPTIQPTQP TTQLPTDSPT QPTTGSFCPG PVTLCSDLES HSTEAVLGDA LVDFSLKLYH AFSAMKKVET NMAFSPFSIA SLLTQVLLGA GENTKTNLES ILSYPKDFTC VHQALKGFTT KGVTSVSQIF HSPDLAIRDT FVNASRTLYS SSPRVLSNNS DANLELINTW VAKNTNNKIS RLLDSLPSDT RL |
Purity Confirmation |
>95% by SDS-PAGE & HPLC analysis |
Synonyms |
Plasma protease C1, C1inh, C1 Esterase Protein, C1-inhibiting factor, Serpin G1 |
Uniprot ID |
P05155 |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.