RN-486

Item no.	MOLN-M10978-25mg
Manufacturer	Molnova
CASRN	1242156-23-5
Amount	25 mg
Category	Reagents & Chemicals Other Chemicals
Type	Chemicals
Specific against	other
Purity	>98% (HPLC)
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Available
Brief description	A potent and selective BTK inhibitor with IC50 of 4 nM in the enzymatic assay; shows high selectivity against a panel of 369 kinases; blocks Fcε receptor cross-linking-induced degranulation in mast cells (IC50=2.9 nM) and Fcγ receptor engagement-mediated TNFα production in monocytes (IC50=7.0 nM); robust anti-inflammatory and bone-protective effects in mouse CIA and rat adjuvant-induced arthritis (AIA) models.Rheumatoid ArthritisPreclinical
Formula Weight	606, 6892
Stability	≥ 2 years
Storage	(-20℃)

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Amount: 25 mg

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