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Pepstatin Ammonium

Pepstatin Ammonium

Item no.	HY-P0018B-5mg
Manufacturer	MedChem Express
Amount	5 mg
Quantity options	10 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Purity	99.76
Formula	C34H66N6O9
Citations	Biol Pharm Bull. 2022 Feb 3.<br/>ACS Nano. 2024 Jan 10.<br/>Int J Antimicrob Agents. 2019 Dec;54(6):814-819.<br/>ACS Nano. 2024 Jun 13.<br/>Adv Sci (Weinh). 2022 Oct 10;e2203831.<br/>Adv Sci (Weinh). 2023 Oct;10(28):e2302130.<br/>Arch Biochem Biophys. 2023 May 22, 109646.<br/>Biochem Bioph Res Co. 2020 Sep 10;530(1):292-300.<br/>Biochem Biophys Res Commun. 2024 Jun 15:725:150271.<br/>bioRxiv. 2023 Nov 5.<br/>Cancer Lett. 2022 Mar 9;215629.<br/>Carbohydr Polym. 2023 Jul 17, 121208.<br/>Cell Death Dis. 2022 Dec 16;13(12):1048.<br/>Cell Rep. 2021 Nov 2;37(5):109931.<br/>Environ Sci Technol. 2017 Dec 5;51(23):13938-13948.<br/>Eur J Pharmacol. 2022 Feb 11;920:174823.<br/>FASEB J. 2022 Jan;36(1):e22121.<br/>Int J Oncol. 2019 Jul;55(1):331-339.<br/>J Virol. 2021 Sep 22;JVI0153721.<br/>J Virol. 2023 Oct 17:e0107523.<br/>Mol Med Rep. 2019 Jan;19(1):41-50.<br/>Mol Pharm. 2024 May 9.<br/>Pharmaceuticals. 2022, 15(12), 1509<br/>Pharmacol Res. 2021 Dec 1;175:105985.<br/>PLoS Pathog. 2024 Feb 14;20(2):e1011981.<br/>Redox Biol. 2024 Apr:70:103064.<br/>Sci Adv. 2022 Nov 11;8(45):eabn6579.<br/>SSRN. 2023 Apr 10.<br/>Toxicol Appl Pharmacol. 2018 Oct 1;356:159-171. <br/>[1]Umezawa H, et al. Pepstatin, a new pepsin inhibitor produced by Actinomycetes. J Antibiot (Tokyo). 1970 May;23(5):259-62.<br/>[2]Seelmeier S, et al. Human immunodeficiency virus has an aspartic-type protease that can be inhibited by pepstatin A. Proc Natl Acad Sci U S A. 1988 Sep;85(18):6612-6.
Smiles	CC(C[C@H](NC([C@@H](NC([C@@H](NC(CC(C)C)=O)C(C)C)=O)C(C)C)=O)[C@@H](O)CC(N[C@@H](C)C(N[C@@H](CC(C)C)[C@@H](O)CC(O)=O)=O)=O)C.N
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	Pepstatin A Ammonium
Available
Product Description	Pepstatin (Pepstatin A) Ammonium is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin Ammonium also inhibits HIV protease[1][2].
StorageTemperature	-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Shipping	Blue Ice
Manufacturers Applications	COVID-19-anti-virus
MolecularWeight	702.92
Clinical Information	No Development Reported
Manufacturers Research Area	Infection; Inflammation/Immunology
Solubility	DMSO : 25 mg/mL (ultrasonic)
Target	Autophagy; HIV Protease
Manufacturers Target	Autophagy; HIV Protease
Manufacturers Pathway	Anti-infection; Autophagy; Metabolic Enzyme/Protease
Manufacturers Product type	Peptides

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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