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DiSC3(5)

DiSC3(5)

Item no.	HY-D0085-50mg
Manufacturer	MedChem Express
CASRN	53213-94-8
Amount	50 mg
Quantity options	100 mg 1ea 25 mg 50 mg
Category	Reagents & Chemicals Staining & Dyes
Type	Reagents
Specific against	other
Purity	99.83
Formula	C25H27IN2S2
Citations	[1]Yamamoto T, et al. Multiple effects of DiS-C3(5) on mitochondrial structure and function. Eur J Biochem. 2004;271(17):3573-3579. <br/>[2]Sims PJ, et al. Studies on the mechanism by which cyanine dyes measure membrane potential in red blood cells and phosphatidylcholine vesicles. Biochemistry. 1974 Jul 30;13(16):3315-30.<br/>[3]Smith TC, et al. The effect of the fluorescent probe, 3,3'-dipropylthiodicarbocyanine iodide, on the membrane potential of Ehrlich ascites tumor cells. Biochem Biophys Res Commun. 1980 Jul 31;95(2):722-7.
Smiles	CCCN1/C(SC2=CC=CC=C12)=C\C=C\C=C\C3=[N+](CCC)C4=CC=CC=C4S3.[I-]
ECLASS 10.1	42051003
ECLASS 11.0	42051003
UNSPSC	12000000
Available
Product Description	DiSC3(5) is a fluorescent probe commonly used as a tracer dye to evaluate mitochondrial membrane potential. The excitation/emission wavelength of DiSC3(5) is up to 622/670 nm. DiSC3(5) can inhibit the respiratory system associated with mitochondrial NAD, and the IC50 value is 8 μM. DiSC3(5) in the presence of Na+/K+-ATPase inhibitor ouabain 2 can induce membrane hyperpolarization of Ehrlich ascites tumor cells[1][2][3].
StorageTemperature	4°C (Powder, sealed storage, away from moisture and light)
Shipping	Room Temperature
MolecularWeight	546.53
Clinical Information	No Development Reported
Manufacturers Research Area	Others
Solubility	DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)
Target	Fluorescent Dye
Manufacturers Target	Fluorescent Dye
Manufacturers Pathway	Others
Manufacturers Product type	Dye Reagents

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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