Item no. |
HY-B1490A-100mg |
Manufacturer |
MedChem Express
|
CASRN |
50-49-7 |
Amount |
100 mg |
Quantity options |
100 mg
10 mg
1 ea
25 mg
50 mg
5 mg
|
Category |
|
Type |
Chemicals |
Specific against |
other |
Purity |
98.78 |
Citations |
Nat Chem Biol. 2024 Feb 14.<br/>Cell Commun Signal. 2023 May 25;21(1):123.<br/>Inflammation. 2021 Jan 29.<br/>Pathogens. 2022 May 22;11(5):602.<br/>[1]Alburquerque-González B, et al. New role of the antidepressant imipramine as a Fascin1 inhibitor in colorectal cancer cells. Exp Mol Med. 2020 Feb;52(2):281-292.<br/>[2]Jeon SH, et al. The tricyclic antidepressant imipramine induces autophagic cell death in U-87MG glioma cells. Biochem Biophys Res Commun. 2011 Sep 23;413(2):311-7. <br/>[3]Xia Z, et al. The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation. J Biochem Mol Toxicol. 1999;13(6):338-47. <br/>[4]Ramirez K, et al. Imipramine attenuates neuroinflammatory signaling and reverses stress-induced social avoidance. Brain Behav Immun. 2015 May;46:212-20.<br/>[5]Balkovetz DF, et al. Evidence for an imipramine-sensitive serotonin transporter in human placental brush-border membranes. J Biol Chem. 1989 Feb 5;264(4):2195-8. |
Smiles |
CN(C)CCCN1C2=CC=CC=C2CCC3=CC=CC=C31 |
ECLASS 10.1 |
32160000 |
ECLASS 11.0 |
32160000 |
UNSPSC |
12000000 |
Available |
|
Product Description |
Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC50 value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects[1][2][3][4][5]. |
StorageTemperature |
-20°C, 3 years; 4°C, 2 years (Powder) |
Shipping |
Room Temperature |
Manufacturers Applications |
COVID-19-immunoregulation |
MolecularWeight |
280.41 |
Clinical Information |
Launched |
Manufacturers Research Area |
Cancer; Inflammation/Immunology; Neurological Disease |
Solubility |
DMSO : 250 mg/mL (ultrasonic) |
Target |
Apoptosis; Autophagy; Serotonin Transporter |
Manufacturers Target |
Apoptosis; Autophagy; Serotonin Transporter |
Manufacturers Pathway |
Apoptosis; Autophagy; Neuronal Signaling |
Manufacturers Product type |
Reference compound |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.