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Mecamylamine (hydrochloride)-13C4,15N

Mecamylamine (hydrochloride)-13C4,15N

Item no.	HY-B1395S1-1mg
Manufacturer	MedChem Express
Amount	1mg
Quantity options	1mg 5mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Formula	C7 13C4H10Cl 15N
Citations	[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. <br/>[2]Bacher I, et al. Mecamylamine - a nicotinic acetylcholine receptor antagonist with potential for the treatment of neuropsychiatric disorders. Expert Opin Pharmacother. 2009 Nov;10(16):2709-21.<br/>[3]Ostroumov K, et al. Modeling study of mecamylamine block of muscle type acetylcholine receptors. Eur Biophys J. 2008 Apr;37(4):393-402.<br/>[4]Rabenstein RL, et al. The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not beta2- or alpha7-nicotinic acetylcholine receptor subunit knockout mice. Psychopharmacology (Berl). 2006 Dec;189(3):395-401.
Smiles	[13C]C1([13C])C([15NH][13C])([13C])C2CCC1C2.[H]Cl
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Available
Product Description	Mecamylamine (hydrochloride)-13C4, 15N is the 13C-labeled and 15N-labeled Mecamylamine hydrochloride. Mecamylamine hydrochloride is an orally active, nonselective, noncompetitive nAChR antagonist that can treat various neuropsychiatric disorders. Mecamylamine hydrochloride is originally used as a ganglionic blocker in treating hypertension. Mecamylamine hydrochloride can easily crosses the blood-brain barrier[1][2].
Shipping	Room temperature
MolecularWeight	196.62
Clinical Information	No Development Reported
Manufacturers Research Area	Neurological Disease
Solubility	10 mM in DMSO
Target	Isotope-Labeled Compounds; nAChR
Manufacturers Target	Isotope-Labeled Compounds; nAChR
Manufacturers Pathway	Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Manufacturers Product type	Isotope-Labeled Compounds

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