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Vacquinol-1

Vacquinol-1

Item no.	HY-19345-100mg
Manufacturer	MedChem Express
CASRN	5428-80-8
Amount	100 mg
Quantity options	100 mg 1 ea
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Citations	[1]Sun SL, Li X, Su N, et al. Vacquinol‑1 induces apoptosis in hepatocellular carcinoma cell. Mol Med Rep. 2018;18(1):557-563.<br/>[2]Sander P, Mostafa H, Soboh A, et al. Vacquinol-1 inducible cell death in glioblastoma multiforme is counter regulated by TRPM7 activity induced by exogenous ATP. Oncotarget. 2017;8(21):35124-35137. <br/>[3]Chao Wu, et al. Salvianolic acid B exerts anti-liver fibrosis effects via inhibition of MAPK-mediated phospho-Smad2/3 at linker regions in vivo and in vitro. Life Sci. 2019 Dec 15;239:116881.<br/>[4]Yufeng Shi, et al. The soft underbelly of tumor cells. Cell Res. 2014 Aug;24(8):910-1.<br/>[5]Shu-Lan Sun, et al. Vacquinol 1 induces apoptosis in hepatocellular carcinoma cell. Mol Med Rep. 2018 Jul;18(1):557-563.
Smiles	OC(C1NCCCC1)C2=CC(C3=CC=C(Cl)C=C3)=NC4=CC=CC=C24
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	NSC13316
Available
Product Description	Vacquinol-1 (NSC13316) is a MKK4-specific activator that activates MAPK pathways[1]. Vacquinol-1 specifically induces human glioblastoma cell (GC) death, attenuates tumor progression and prolongs survival in a glioblastoma multiforme (GBM) mouse model[2]. Vacquinol-1 also induces apoptosis in hepatocellular carcinoma (HCC)cell[3].
Shipping	Room temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	352.86
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 30 mg/mL (ultrasonic; warming)
Target	Others
Manufacturers Target	Others
Manufacturers Pathway	Others
Manufacturers Product type	Reference compound

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