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SHP2-D26

SHP2-D26

Item no.	HY-145162-100mg
Manufacturer	MedChem Express
CASRN	2458219-65-1
Amount	100 mg
Quantity options	100 mg 10 mg 1 ea 1 mg 25 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	95.03
Citations	[1]Wang M, et al. Discovery of SHP2-D26 as a First, Potent, and Effective PROTAC Degrader of SHP2 Protein [published correction appears in J Med Chem. 2021 Jan 14;64(1):906-908]. J Med Chem. 2020;63(14):7510-7528.
Smiles	ClC(C(SC1=NC=C(N2CCC(N)(CC2)C)N=C1N)=CC=C3)=C3NC(CCC(N(CC4)CCN4CCCCCCCCC(N[C@@H](C(C)(C)C)C(N5[C@@H](C[C@H](C5)O)C(N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C)=O)=O)=O)=O)=O
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Available
Product Description	SHP2-D26 is a first, potent and effective SHP2 degrader. SHP2-D26 induces SHP2 degradation requires binding to VHL-1 and SHP2 proteins. SHP2-D26 is also neddylation- and proteasome-dependent[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	1115.89
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 83.33 mg/mL (ultrasonic)
Target	Phosphatase; PROTACs; SHP2
Manufacturers Target	Phosphatase; PROTACs; SHP2
Manufacturers Pathway	Metabolic Enzyme/Protease; PROTAC; Protein Tyrosine Kinase/RTK
Manufacturers Product type	Reference compound

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