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A2AAR/HDAC-IN-1

A2AAR/HDAC-IN-1

Item no.	HY-143324-100mg
Manufacturer	MedChem Express
CASRN	2767560-51-8
Amount	100 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Citations	[1]Zhang J, et al. Dual-acting antitumor agents targeting the A2A adenosine receptor and histone deacetylases: Design and synthesis of 4-(furan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine derivatives. Eur J Med Chem. 2022 Jun 5;236:114326.
Smiles	NC1=CC=CC=C1NC(C2=CC=C(C=C2)CCN3N=CC4=C(N=C(N=C43)N)C5=CC=CO5)=O
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Available
Product Description	A2AAR/HDAC-IN-1 (compound 14c) is an orally active, potent and balanced A2AAR/HDAC dual inhibitor, with a Ki of 163.5 nM for A2AAR and an IC50 of 145.3 nM for HDAC1. A2AAR/HDAC-IN-1 shows anticancer activity[1].
Shipping	Room temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	439.47
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer
Solubility	10 mM in DMSO
Manufacturers Target	Adenosine Receptor; HDAC
Isoform	Adenosine A1 receptor (A1R); Adenosine A2A receptor (A2AR); Adenosine A2B receptor (A2BR); Adenosine A3 receptor (A3R); HDAC1; HDAC2; HDAC3; HDAC6; HDAC8
Pathway	Cell Cycle/DNA Damage; Epigenetics; GPCR/G Protein
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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