BGT226

Item no.	HY-13334A-100mg
Manufacturer	MedChem Express
CASRN	915020-55-2
Amount	100 mg
Quantity options	100 mg 10mM/1mL 10 mg 1 ea 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	99.51
Formula	C28H25F3N6O2
Citations	Molecules. 2020 Apr 23;25(8):1980.<br/>Arch Pharm (Weinheim). 2024 May 29:e2400066.<br/>Front Pharmacol. 2020 Nov 11;11:580407.<br/>Harvard Medical School LINCS LIBRARY<br/>Research Square Print. 2023 Mar 9.<br/>Sci Transl Med. 2018 Jul 18;10(450):eaaq1093.<br/>[1]Markman B, et al. Phase I safety, pharmacokinetic, and pharmacodynamic study of the oral phosphatidylinositol-3-kinase and mTOR inhibitor BGT226 in patients with advanced solid tumors. Ann Oncol. 2012 Sep;23(9):2399-408.<br/>[2]Chang KY, et al. Novel phosphoinositide 3-kinase/mTOR dual inhibitor, NVP-BGT226, displays potent growth-inhibitory activity against human head and neck cancer cells in vitro and in vivo. Clin Cancer Res. 2011 Nov 15;17(22):7116-26.
Smiles	O=C(N1C2=CC=C(N3CCNCC3)C(C(F)(F)F)=C2)N(C)C4=C1C5=CC(C6=CC=C(OC)N=C6)=CC=C5N=C4
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	NVP-BGT226
Available
Product Description	BGT226 (NVP-BGT226) is a PI3K (with IC50s of 4 nM, 63 nM and 38 nM for PI3Kα, PI3Kβ and PI3Kγ)/mTOR dual inhibitor which displays potent growth-inhibitory activity against human head and neck cancer cells[1][2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	534.53
Clinical Information	Phase 2
Manufacturers Research Area	Cancer
Solubility	DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Target	Autophagy; mTOR; PI3K
Manufacturers Target	Autophagy; mTOR; PI3K
Isoform	mTOR; PI3Kα; PI3Kβ; PI3Kγ
Manufacturers Pathway	Autophagy; PI3K/Akt/mTOR
Manufacturers Product type	Reference compound

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