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c-di-AMP (diammonium)

c-di-AMP (diammonium)

Item no.	HY-12326B-5mg
Manufacturer	MedChem Express
Amount	5 mg
Quantity options	10 mg 1 mg 25 mg 500 ug 50 mg 5 mg
Category	Reagents & Chemicals Other Chemicals
Type	Reagents
Specific against	other
Purity	99.36
Formula	C20H30N12O12P2
Citations	[1]Fahmi T, et al. c-di-AMP: An Essential Molecule in the Signaling Pathways that Regulate the Viability and Virulenceof Gram-Positive Bacteria. Genes (Basel). 2017 Aug 7;8(8).<br/>[2]Ning H, et al. Recombinant BCG With Bacterial Signaling Molecule Cyclic di-AMP as Endogenous AdjuvantInduces Elevated Immune Responses After Mycobacterium tuberculosis Infection. Front Immunol. 2019 Jul 3;10:1519.<br/>[3]Ebensen T, et al. The Combination Vaccine Adjuvant System Alum/c-di-AMP Results in Quantitative and QualitativeEnhanced Immune Responses Post Immunization. Front Cell Infect Microbiol. 2019 Feb 19;9:31.<br/>[4]Sanchez MV, et al. Intranasal delivery of influenza rNP adjuvanted with c-di-AMP induces strong humoral and cellularimmune responses and provides protection against virus challenge. PLoS One. 2014 Aug 20;9(8):e104824.
Smiles	O[C@H]([C@@](OP(O)(OC[C@](O[C@@H](N1C2=NC=NC(N)=C2N=C1)[C@@H]3O)([H])[C@@]3([H])O4)=O)([H])[C@](COP4(O)=O)([H])O5)[C@@H]5N6C7=NC=NC(N)=C7N=C6.N.N
ECLASS 10.1	42051003
ECLASS 11.0	42051003
UNSPSC	12000000
Alias	Cyclic diadenylate (diammonium); Cyclic-di-AMP (diammonium)
Available
Product Description	c-di-AMP diammonium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP diammonium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP diammonium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses[1][2][3][4].
StorageTemperature	-20°C (Powder, sealed storage, away from moisture)
Shipping	Blue Ice
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	692.47
Clinical Information	No Development Reported
Manufacturers Research Area	Inflammation/Immunology
Solubility	DMSO : < 1 mg/mL (ultrasonic; warming; heat to 60°C)
Target	Bacterial; Endogenous Metabolite; STING
Manufacturers Target	Bacterial; Endogenous Metabolite; STING
Manufacturers Pathway	Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

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