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(R,R)-CXCR2-IN-2

(R,R)-CXCR2-IN-2

Item no.	HY-120878A-10mM
Manufacturer	MedChem Express
CASRN	1838123-22-0
Amount	10mM/1mL
Quantity options	100 mg 10mM/1mL 10 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Purity	99.37
Formula	C18H23ClN2O5S
Citations	[1]Lu H, et al. Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists. J Med Chem. 2018;61(6):2518-2532.
Smiles	O=S(C1=C(C(NC(N[C@H]2C(C)=CCC2)=O)=CC=C1Cl)O)([C@@]3(CCOC3)C)=O
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	1838123-22-0
Available
Product Description	(R, R)-CXCR2-IN-2, diastereoisomer of CXCR2-IN-2 (compound 68), is a brain penetrant CXCR2 antagonist with a pIC50 of 9 and 6.8 in the Tango assay and d in the HWB Gro-α induced CD11b expression assay, respectively[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	414.90
Clinical Information	No Development Reported
Manufacturers Research Area	Inflammation/Immunology
Solubility	DMSO : 220 mg/mL (ultrasonic)
Target	CXCR
Manufacturers Target	CXCR
Manufacturers Pathway	GPCR/G Protein; Immunology/Inflammation
Manufacturers Product type	Reference compound

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