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Meclofenamic acid-d4

Meclofenamic acid-d4

Item no.	HY-117275S-1mg
Manufacturer	MedChem Express
CASRN	1185072-18-7
Amount	1 mg
Quantity options	10 mg 1 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Formula	C14H7D4Cl2NO2
Citations	[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. <br/>[2]Conroy MC, et al. Pharmacology, pharmacokinetics, and therapeutic use of meclofenamate sodium. Clin J Pain. 1991;7 Suppl 1:S44-8.<br/>[3]Eleftheriou CG, et al. Meclofenamic acid improves the signal to noise ratio for visual responses produced by ectopicexpression of human rod opsin. Mol Vis. 2017 Jun 16;23:334-345. eCollection 2017.<br/>[4]Huang Y, et al. Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5. Nucleic Acids Res. 2015 Jan;43(1):373-84.
Smiles	ClC(C(C)=CC=C1Cl)=C1NC2=C(C([2H])=C([2H])C([2H])=C2[2H])C(O)=O
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	Meclofenamate-d4
Available
Product Description	Meclofenamic acid-d4 is the deuterium labeled Meclofenamic acid. Meclofenamic Acid (Meclofenamate), a non-steroidal, anti-inflammatory agent, is a highly selective fat mass and obesity-associated (FTO) enzyme inhibitor. Meclofenamic Acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker[1][2][3].
Shipping	Room temperature
MolecularWeight	300.17
Clinical Information	No Development Reported
Manufacturers Research Area	Inflammation/Immunology
Solubility	10 mM in DMSO
Target	Endogenous Metabolite; Gap Junction Protein; Isotope-Labeled Compounds
Manufacturers Target	Endogenous Metabolite; Gap Junction Protein; Isotope-Labeled Compounds
Manufacturers Pathway	Cytoskeleton; Metabolic Enzyme/Protease; Others
Manufacturers Product type	Isotope-Labeled Compounds

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