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7-Hydroxycoumarinyl arachidonate

7-Hydroxycoumarinyl arachidonate

Item no.	HY-116141-5mg
Manufacturer	MedChem Express
CASRN	161180-11-6
Amount	5 mg (55.73 mM * 200 ul ethanol)
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Purity	98.0
Formula	C29H36O4
Citations	[1]Yuren Wang, et al. A fluorescence-based assay for monoacylglycerol lipase compatible with inhibitor screening. Assay Drug Dev Technol. 2008 Jun;6(3):387-93.<br>[2]Z Huang, et al. A continuous fluorescence-based assay for the human high-molecular-weight cytosolic phospholipase A2. Anal Biochem. 1994 Oct;222(1):110-5.<br>[3]R T Pickard, et al. Identification of essential residues for the catalytic function of 85-kDa cytosolic phospholipase A2. Probing the role of histidine, aspartic acid, cysteine, and arginine. J Biol Chem. 1996 Aug 9;271(32):19225-31.
Smiles	CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(OC1=CC=C2C=CC(OC2=C1)=O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	7-HCA; Umbelliferyl Arachidonate; 7-HC-arachidonate
Available
Product Description	7-Hydroxycoumarinyl arachidonate (7-HCA) is a fluorogenic substrate of cytosolic phospholipase A2 (PLA2). 7-Hydroxycoumarinyl arachidonate is also a fluorogenic substrate for monoacylglycerol lipase (MAGL). MAGL protein catalyzes the hydrolysis of 7-Hydroxycoumarinyl arachidonat to generate Arachidonic acid (AA) and the highly fluorescent 7-hydroxyl coumarin (7-HC; HY-N0573). Release of 7-HC can be measured using a fluorometer[1][2][3].
StorageTemperature	Solution, -20°C, 2 years
Shipping	Blue Ice
Manufacturers Applications	Metabolism-sugar/lipid metabolism
MolecularWeight	448.59
Clinical_Information	No Development Reported
Manufacturers Research_Area	Others
Solubility	10 mM in DMSO
Manufacturers Target	MAGL; Phospholipase
Pathway	Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

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Amount: 5 mg (55.73 mM * 200 ul ethanol)

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