AEM1

Item no.	HY-113848-100mg
Manufacturer	MedChem Express
CASRN	1030123-90-0
Amount	100 mg
Quantity options	100 mg 10 mg 1 ea 1 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	98.99
Formula	C20H14FN3O2S
Citations	[1]DeNicola GM, et al. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature. 2011 Jul 6;475(7354):106-9. [2]Bollong MJ, Yun H, Sherwood L, Woods AK, Lairson LL, Schultz PG. A Small Molecule Inhibits Deregulated NRF2 Transcriptional Activity in Cancer. ACS Chem Biol. 2015 Oct 16;10(10):2193-8.
Smiles	FC1=CC=C(C2=CSC3=NC=NC(NCC4=CC=C(OCO5)C5=C4)=C32)C=C1
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Available
Product Description	AEM1 is a Nrf2 inhibitor[1]. AEM1 reduces the expressions of Nrf2-dependent genes in A549 cells and inhibits the growth of A549 cells in vitro and in vivo[2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	379.41
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 100 mg/mL (ultrasonic)
Target	Keap1-Nrf2
Manufacturers Target	Keap1-Nrf2
Manufacturers Pathway	NF-κB
Manufacturers Product type	Reference compound

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HY-113848-100mg-safety-datasheet.pdf