AC-186

Item no.	HY-110157-100mg
Manufacturer	MedChem Express
CASRN	1421854-16-1
Amount	100 mg
Quantity options	100 mg 10 mg 1 ea 1 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	99.61
Citations	[1]McFarland K, et al. AC-186, a selective nonsteroidal estrogen receptor β agonist, shows gender specific neuroprotection in a Parkinson's disease rat model. ACS Chem Neurosci. 2013 Sep 18;4(9):1249-55.<br/>[2]Jian-Nong Ma, et al. Estrogen Receptor Beta Selective Agonists as Agents to Treat Chemotherapeutic-Induced Neuropathic Pain. ACS Chem Neurosci. 2016 Sep 21;7(9):1180-7.
Smiles	FC1=C(C=CC=C1)C2(C3=CC=C(O)C=C3)CCC(F)(F)CC2
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Available
Product Description	AC-186 is a selective non-steroidal estrogen receptor β (ERβ) agonist with EC50s of 6 nM and 5000 nM for ERβ and ERα, respectively. AC-186 shows gender selective neuroprotective effects in a male rat model of Parkinson's disease[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neurodegeneration
MolecularWeight	306.32
Clinical Information	No Development Reported
Manufacturers Research Area	Neurological Disease
Solubility	DMSO : 100 mg/mL (ultrasonic)
Target	Estrogen Receptor/ERR
Manufacturers Target	Estrogen Receptor/ERR
Isoform	ERα; ERβ
Manufacturers Pathway	Vitamin D Related/Nuclear Receptor
Manufacturers Product type	Reference compound

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