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AMG8379

AMG8379

Item no.	HY-108425-100mg
Manufacturer	MedChem Express
CASRN	1642112-31-9
Amount	100 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Citations	[1]Kornecook TJ, et al. Pharmacologic Characterization of AMG8379, a Potent and Selective Small Molecule Sulfonamide Antagonist of the Voltage-Gated Sodium Channel NaV1.7. J Pharmacol Exp Ther. 2017 Jul;362(1):146-160.
Smiles	O=S(NC1=NOC=C1)(C2=CC(C=CC(N3C4=C(OC)C=C(C(F)=C4)C5=CC(Cl)=CC(F)=C5)=O)=C3C=C2)=O
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Available
Product Description	AMG8379 is a potent, orally active and selective sulfonamide antagonist of the voltage-gated sodium channel NaV1.7, with IC50s of 8.5 and 18.6 nM for hNaV1.7 and mNaV1.7, respectively. AMG8379 potently and reversibly blocks endogenous Tetrodotoxin (TTX)-sensitive sodium channels in dorsal root ganglia (DRG) neurons with an IC50 of 3.1 nM[1].
Shipping	Room temperature
Manufacturers Applications	Neuroscience-Neuromodulation
MolecularWeight	543.93
Clinical_Information	No Development Reported
Manufacturers Research_Area	Neurological Disease
Solubility	10 mM in DMSO
Manufacturers Target	Sodium Channel
Isoform	Nav1.7
Pathway	Membrane Transporter/Ion Channel
Manufacturers Product type	Reference compound

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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