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S-methyl-KE-298

S-methyl-KE-298

Item no.	HY-101671-100mg
Manufacturer	MedChem Express
CASRN	143584-75-2
Amount	100 mg
Quantity options	100 mg 10 mg 1 ea 1mg 20mg 50 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	98.0
Citations	[1]Yoshida H, et al. Identification of metabolites of KE-298, a new antirheumatic drug, and its physiological properties in rats. Biol Pharm Bull. 1996 Mar;19(3):424-9.<br/>[2]Endo H, et al. Stereoselectivity and species difference in plasma protein binding of KE-298 and its metabolites. Biol Pharm Bull. 2001 Jul;24(7):800-5.<br/>[3]Honda S, et al. Expression of membrane-type 1 matrix metalloproteinase in rheumatoid synovial cells. Clin Exp Immunol. 2001 Oct;126(1):131-6.
Smiles	CSCC(C(O)=O)CC(C1=CC=C(C)C=C1)=O
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	M-2
Available
Product Description	S-methyl-KE-298 is an active metabolite of KE-298. KE-298 inhibits matrix metalloproteinase (MMP-1) production from rheumatoid arthritis (RA) synovial cells.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neuromodulation
MolecularWeight	252.33
Clinical Information	Phase 2
Manufacturers Research Area	Inflammation/Immunology
Solubility	DMSO : 100 mg/mL (ultrasonic)
Target	Drug Metabolite; MMP
Manufacturers Target	Drug Metabolite; MMP
Manufacturers Pathway	Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

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