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(-)-Bicuculline (methochloride)

(-)-Bicuculline (methochloride)

Item no.	HY-100783A-100mg
Manufacturer	MedChem Express
CASRN	53552-05-9
Amount	100 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Citations	[1]Seutin V, et al. Recent advances in the pharmacology of quaternary salts of bicuculline. Trends Pharmacol Sci. 1999 Jul;20(7):268-70.<br>[2]Okazaki R, et al. The antiallodynic effect of Neurotropin is mediated via activation of descending pain inhibitory systems in rats with spinal nerve ligation. Anesth Analg. 2008 Sep;107(3):1064-9.
Smiles	C[N+]1(C)[C@@H]([C@H]2OC(C3=C4OCOC4=CC=C32)=O)C5=C(C=C6C(OCO6)=C5)CC1.[Cl-]
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	l-Bicuculline (methochloride)
Available
Product Description	(-)-Bicuculline methochloride (l-Bicuculline methochloride) is a potent GABAA receptor antagonist. (-)-Bicuculline methochloride blocks afterhyperpolarizations (AHPs) mediated by Ca2+-activated K+ channels in various types of neurons[1].
Shipping	Room temperature
Manufacturers Applications	Neuroscience-Neuromodulation
MolecularWeight	417.84
Clinical_Information	No Development Reported
Manufacturers Research_Area	Neurological Disease
Solubility	10 mM in DMSO
Manufacturers Target	GABA Receptor
Pathway	Membrane Transporter/Ion Channel; Neuronal Signaling
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 mg

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