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Lesogaberan

Lesogaberan

Item no.	HY-10061-10mg
Manufacturer	MedChem Express
CASRN	344413-67-8
Amount	10 mg
Quantity options	10 mg 1 ea 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Citations	[1]Lehmann A, et al. (R)-(3-amino-2-fluoropropyl) phosphinic acid (AZD3355), a novel GABAB receptor agonist, inhibits transient lower esophageal sphincter relaxation through a peripheral mode of action. J Pharmacol Exp Ther. 2009 Nov;331(2):504-12.<br/>[2]Tian J, et al. Repurposing Lesogaberan to Promote Human Islet Cell Survival and β-Cell Replication. J Diabetes Res. 2017;2017:6403539.
Smiles	O=P(C[C@H](F)CN)O
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	AZD-3355
Available
Product Description	Lesogaberan (AZD-3355) is a potent and selective GABAB receptor agonist with an EC50 of 8.6 nM for human recombinant GABAB receptors. The affinity (Kis) of Lesogaberan for rat GABAB and GABAA receptors, as measured by displacement of [3H]GABA binding in brain membranes: 5.1 nM and 1.4 μM, respectively. Lesogaberan inhibits transient lower esophageal sphincter relaxation through a peripheral mode of action[1].
Shipping	Room temperature
Manufacturers Applications	Metabolism-protein/nucleotide metabolism
MolecularWeight	141.08
Clinical Information	Phase 2
Manufacturers Research Area	Metabolic Disease
Solubility	10 mM in DMSO
Target	GABA Receptor
Manufacturers Target	GABA Receptor
Manufacturers Pathway	Membrane Transporter/Ion Channel; Neuronal Signaling
Manufacturers Product type	Reference compound

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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