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BMS-986176

BMS-986176

Item no.	DCC-DC58041-100mg
Manufacturer	DCChemicals
CASRN	1815613-42-3
Amount	100 mg
Category	Reagents & Chemicals Molecules
Type	Chemicals
Applications	IC, IS
Specific against	other
Smiles	FC(F)C1=CC(C2N=C(C(F)F)C(OC[C@@](N)(CC(C)C)C)=CC=2)=CC=N1
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Available
Fields of application	AAK1-IN-1(BMS-986176) is a chemical probe for AAK1 and BIKE that potently targets the ATP-binding site (AAK1 Ki = 9.1 nM; BIKE Ki = 17 nM). Regarding kinase selectivity, only three kinases were observed to bind SGC-AAK1-1 within 30-fold of the KD of AAK1 in a KINOMEscan assay (DiscoverX) at 1 μM followed by KD determinations: RIOK1 (KD = 72 nM), RIOK3 (KD = 290 nM), and PIP5K1C (KD = 260 nM). In a live cell NanoBRET assay (Promega) SGC-AAK1-1 has potency for ectopically expressed full-length AAK1- and BIKE-Nluc fusion proteins (AAK1 IC50 = 230 nM; BIKE IC50 = 1.5 μM).
MOLECULE WEIGHT	385, 399

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 mg

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