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Apostatin-1 (Apt-1)

Apostatin-1 (Apt-1)

Item no.	DCC-DC39045-250mg
Manufacturer	DCChemicals
CASRN	2559703-06-7
Amount	250 mg
Category	Reagents & Chemicals Molecules
Type	Chemicals
Applications	IC, IS
Specific against	other
Smiles	S(C1=NC([H])([H])C([H])([H])N1C([H])([H])[H])C([H])(C1C([H])=C([H])C([H])=C([H])C=1[H])C(N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])=O
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Available
Fields of application	Apostatin-1 (Apt-1) is a novel TRADD inhibitor.Apostatin-1 inhibits RIPK1-dependent apoptosis (RDA) with IC50 of 1.28 μM and shows no significant off-target activity on 97 kinases in KINOME scan profiling.Inhibition of TRADD by Apostatin-1 blocks apoptosis and restores cellular homeostasis by activating autophagy in cells with accumulated mutant tau, α-synuclein, or huntingtin. Treatment with Apt-1 restored proteostasis and inhibited cell death in a mouse model of proteinopathy induced by mutant tau(P301S).
MOLECULE WEIGHT	345, 5

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Amount: 250 mg

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Delivery expected until 9/6/2024

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