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Tubulysin I

Tubulysin I

Item no.	HY-N7052-5mg
Manufacturer	MedChem Express
CASRN	799822-10-9
Amount	5mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Formula	C40H59N5O10S
Citations	[1]Kubicek K, et al. The tubulin-bound structure of the antimitotic drug tubulysin. Angew Chem Int Ed Engl. 2010 Jun 28;49(28):4809-12.<br>[2]Vlahov IR, et al. Acid mediated formation of an N-acyliminium ion from tubulysins: a new methodology for the synthesis of natural tubulysins and their analogs. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6778-81.
Smiles	O=C([C@@H]1N(CCCC1)C)N[C@]([C@@H](C)CC)([H])C(N(COC(C)=O)[C@@H](C(C)C)C[C@H](C2=NC(C(N[C@H](C[C@H](C)C(O)=O)CC3=CC=C(O)C=C3)=O)=CS2)OC(C)=O)=O
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Available
Product Description	Tubulysin I is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin I can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin I displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the low nanomolar range. Tubulysin I inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis[1][2].
Shipping	Room temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	801.99
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer
Solubility	10 mM in DMSO
Manufacturers Target	ADC Cytotoxin; Microtubule/Tubulin
Pathway	Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton
Manufacturers Product type	Natural Products

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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