Item no. |
HY-N1724-50ug |
Manufacturer |
MedChem Express
|
CASRN |
80890-47-7 |
Amount |
50 ug |
Quantity options |
100ug
1mg
25 ug
50 ug
|
Category |
|
Type |
Chemicals |
Specific against |
other |
Purity |
99.0 |
Formula |
C46H75NO14 |
Citations |
[3]Hines IN, et al. Impaired T cell-mediated hepatitis in peroxisome proliferator activated receptor alpha (PPARα)-deficient mice. Biol Res. 2018 Feb 15;51(1):5.<br/>[4]Woo JT, et al. Isolation, characterization and biological activities of concanamycins as inhibitors of lysosomal acidification. J Antibiot (Tokyo). 1992 Jul;45(7):1108-16.<br/>[5]Vaněk, Z., et al. Immunomodulators isolated from microorganisms. Folia Microbiol. 1991. 36:99–111. <br/>[1]Togashi K, et al. Concanamycin A, a vacuolar type H(+)-ATPase inhibitor, induces cell death in activated CD8(+) CTL. Cytotechnology. 1997 Nov;25(1-3):127-35.<br/>[2]Eswarappa SM, et al. Folimycin (concanamycin A) inhibits LPS-induced nitric oxide production and reduces surface localization of TLR4 in murine macrophages. Innate Immun. 2008 Feb;14(1):13-24. |
Smiles |
C[C@H]([C@@](C[C@H]1O[C@@](O[C@H](C)[C@H]2OC(N)=O)([H])C[C@H]2O)(O[C@H](/C=C/C)[C@H]1C)O)[C@H](O)[C@@H]([C@](OC(/C(OC)=C/C(C)=C/[C@H]([C@@H](O)[C@H]3CC)C)=O)([H])[C@H](/C=C/C=C(C[C@H]([C@@H]3O)C)/C)OC)C |
ECLASS 10.1 |
32160000 |
ECLASS 11.0 |
32160000 |
UNSPSC |
12000000 |
Alias |
Antibiotic X 4357B; Folimycin; X 4357B |
Available |
|
Product Description |
Concanamycin A (Folimycin; Antibiotic X 4357B) is a macrolide antibiotic, a vacuolar type H+-ATPase (V-ATPase) inhibitor. Concanamycin A is also an inhibitor of lysosomal acidification, can be used to T cell-mediated inflammation research[1]-[5]. |
StorageTemperature |
-20°C, 3 years (Powder) |
Shipping |
Blue Ice |
Manufacturers Applications |
Cancer-programmed cell death |
MolecularWeight |
866.09 |
Clinical Information |
No Development Reported |
Manufacturers Research Area |
Cancer; Infection; Inflammation/Immunology |
Solubility |
DMSO : ≥ 10 mg/mL|Methanol : 10 mg/mL (ultrasonic; warming) |
Target |
Antibiotic; Bacterial; Proton Pump |
Manufacturers Target |
Antibiotic; Bacterial; Proton Pump |
Isoform |
Macrolide |
Manufacturers Pathway |
Anti-infection; Membrane Transporter/Ion Channel |
Manufacturers Product type |
Natural Products |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.