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Concanamycin A

Concanamycin A

Item no.	HY-N1724-50ug
Manufacturer	MedChem Express
CASRN	80890-47-7
Amount	50 ug
Quantity options	100ug 1mg 25 ug 50 ug
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	99.0
Formula	C46H75NO14
Citations	[3]Hines IN, et al. Impaired T cell-mediated hepatitis in peroxisome proliferator activated receptor alpha (PPARα)-deficient mice. Biol Res. 2018 Feb 15;51(1):5.<br/>[4]Woo JT, et al. Isolation, characterization and biological activities of concanamycins as inhibitors of lysosomal acidification. J Antibiot (Tokyo). 1992 Jul;45(7):1108-16.<br/>[5]Vaněk, Z., et al. Immunomodulators isolated from microorganisms. Folia Microbiol. 1991. 36:99–111. <br/>[1]Togashi K, et al. Concanamycin A, a vacuolar type H(+)-ATPase inhibitor, induces cell death in activated CD8(+) CTL. Cytotechnology. 1997 Nov;25(1-3):127-35.<br/>[2]Eswarappa SM, et al. Folimycin (concanamycin A) inhibits LPS-induced nitric oxide production and reduces surface localization of TLR4 in murine macrophages. Innate Immun. 2008 Feb;14(1):13-24.
Smiles	C[C@H]([C@@](C[C@H]1O[C@@](O[C@H](C)[C@H]2OC(N)=O)([H])C[C@H]2O)(O[C@H](/C=C/C)[C@H]1C)O)[C@H](O)[C@@H]([C@](OC(/C(OC)=C/C(C)=C/[C@H]([C@@H](O)[C@H]3CC)C)=O)([H])[C@H](/C=C/C=C(C[C@H]([C@@H]3O)C)/C)OC)C
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	Antibiotic X 4357B; Folimycin; X 4357B
Available
Product Description	Concanamycin A (Folimycin; Antibiotic X 4357B) is a macrolide antibiotic, a vacuolar type H+-ATPase (V-ATPase) inhibitor. Concanamycin A is also an inhibitor of lysosomal acidification, can be used to T cell-mediated inflammation research[1]-[5].
StorageTemperature	-20°C, 3 years (Powder)
Shipping	Blue Ice
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	866.09
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer; Infection; Inflammation/Immunology
Solubility	DMSO : ≥ 10 mg/mL\|Methanol : 10 mg/mL (ultrasonic; warming)
Target	Antibiotic; Bacterial; Proton Pump
Manufacturers Target	Antibiotic; Bacterial; Proton Pump
Isoform	Macrolide
Manufacturers Pathway	Anti-infection; Membrane Transporter/Ion Channel
Manufacturers Product type	Natural Products

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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