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Fenofibrate-d6

Fenofibrate-d6

Item no.	HY-17356S-5mg
Manufacturer	MedChem Express
CASRN	1092484-56-4
Amount	5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Formula	C20H15D6ClO4
Citations	[1]Schelleman H, et al. Pharmacoepidemiologic and in vitro evaluation of potential drug-drug interactions of sulfonylureas with fibrates and statins. Br J Clin Pharmacol. 2014 Sep;78(3):639-48.<br>[2]Gong Y, et al. Fenofibrate Inhibits Cytochrome P450 Epoxygenase 2C Activity to Suppress Pathological Ocular Angiogenesis. EBioMedicine. 2016 Sep 30. pii: S2352-3964(16)30448-0.<br>[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
Smiles	ClC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC(C(OC(C)C)=O)(C([2H])([2H])[2H])C([2H])([2H])[2H])=O
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Available
Product Description	Fenofibrate-d6 is the deuterium labeled Fenofibrate. Fenofibrate is a selective PPARα agonist with an EC50 of 30 μM. Fenofibrate also inhibits human cytochrome P450 isoforms, with IC50s of 0.2, 0.7, 9.7, 4.8 and 142.1 μM for CYP2C19, CYP2B6, CYP2C9, CYP2C8, and CYP3A4, respectively.
Shipping	Room temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	366.87
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cardiovascular Disease; Cancer
Solubility	10 mM in DMSO
Manufacturers Target	Autophagy; Cytochrome P450; Isotope-Labeled Compounds; PPAR
Isoform	CYP2; CYP3
Pathway	Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor
Manufacturers Product type	Isotope-Labeled Compounds

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