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AZD1208 (hydrochloride)

AZD1208 (hydrochloride)

Item no.	HY-15604A-1ea
Manufacturer	MedChem Express
CASRN	1621866-96-3
Amount	1 ea
Quantity options	100 mg 10mg 1 ea 50mg 5mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Formula	C21H22ClN3O2S
Citations	[1]Dakin LA, et al. Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4599-604.<br/>[2]Kreuz S, et al. Loss of PIM2 enhances the anti-proliferative effect of the pan-PIM kinase inhibitor AZD1208 in non-Hodgkin lymphomas. Mol Cancer. 2015 Dec 8;14:205.<br/>[3]Harada M, et al. The novel combination of dual mTOR inhibitor AZD2014 and pan-PIM inhibitor AZD1208 inhibits growth in acute myeloid leukemia via HSF pathway suppression. Oncotarget. 2015 Nov 10;6(35):37930-47.
Smiles	O=C(NC/1=O)SC1=C/C2=C(N3C[C@H](N)CCC3)C(C4=CC=CC=C4)=CC=C2.[H]Cl
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Available
Product Description	AZD1208 hydrochloride is an orally bioavailable, highly selective PIM kinases inhibitor[1].
Shipping	Room temperature
Manufacturers Applications	Neuroscience-Neuromodulation
MolecularWeight	415.94
Clinical Information	Phase 1
Manufacturers Research Area	Cancer
Solubility	DMSO : 83.3 mg/mL (ultrasonic; warming)
Target	Apoptosis; Autophagy; Pim
Manufacturers Target	Apoptosis; Autophagy; Pim
Isoform	PIM2
Manufacturers Pathway	Apoptosis; Autophagy; JAK/STAT Signaling
Manufacturers Product type	Reference compound

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