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Thalidomide-d4

Thalidomide-d4

Item no.	HY-14658S-1mg
Manufacturer	MedChem Express
CASRN	1219177-18-0
Amount	1 mg
Quantity options	10mg 1 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	98.03
Formula	C13H6D4N2O4
Citations	[1]Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53.<br/>[2]Sun X, et al. Synergistic Inhibition of Thalidomide and Icotinib on Human Non-Small Cell Lung Carcinomas Through ERK and AKT Signaling. Med Sci Monit. 2018 May 15;24:3193-3203.
Smiles	O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C([2H])=C([2H])C([2H])=C3[2H])=O
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Available
Product Description	Thalidomide-d4 is a deuterium labeled Thalidomide. Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ~250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties[1][2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	262.25
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer; Inflammation/Immunology
Solubility	10 mM in DMSO
Target	Apoptosis; Autophagy; Ligands for E3 Ligase; Molecular Glues
Manufacturers Target	Apoptosis; Autophagy; Ligands for E3 Ligase; Molecular Glues
Isoform	Cereblon
Manufacturers Pathway	Apoptosis; Autophagy; PROTAC
Manufacturers Product type	Isotope-Labeled Compounds

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