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Tramiprosate-d6

Tramiprosate-d6

Item no.	HY-14602S-1mg
Manufacturer	MedChem Express
CASRN	1131576-06-1
Amount	1 mg
Quantity options	10mM/1mL 10 mg 1ea 1 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	98.0
Formula	C3H3D6NO3S
Citations	[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. <br/>[2]Wu S et al. Tramiprosate protects neurons against ischemic stroke by disrupting the interaction between PSD95 and nNOS. Neuropharmacology. 2014 Aug;83:107-17.<br/>[3]Francine Gervais, et al. Targeting soluble Abeta peptide with Tramiprosate for the treatment of brain amyloidosis. Neurobiol Aging. 2007 Apr;28(4):537-47.<br/>[4]R G Fariello, et al. Homotaurine (3 aminopropanesulfonic acid; 3APS) protects from the convulsant and cytotoxic effect of systemically administered kainic acid. Neurology. 1982 Mar;32(3):241-5.
Smiles	O=S(C([2H])([2H])C([2H])([2H])C([2H])([2H])N)(O)=O
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	Homotaurine-d6; 3-Amino-1-propanesulfonic acid-d6
Available
Product Description	Tramiprosate-d6 is the deuterium labeled Tramiprosate. Tramiprosate (Homotaurine), an orally active and brain-penetrant natural amino acid found in various species of red marine algae. Tramiprosate binds to soluble Aβ and maintains Aβ in a non-fibrillar form. Tramiprosate is also a GABA analog and possess neuroprotection, anticonvulsion and antihypertension effects[1][2][3].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
MolecularWeight	145.21
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	H2O : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Target	Amyloid-β
Manufacturers Target	Amyloid-β
Manufacturers Pathway	Neuronal Signaling
Manufacturers Product type	Isotope-Labeled Compounds

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