HQ461

Item no.	HY-144981-50mg
Manufacturer	MedChem Express
CASRN	1226443-41-9
Amount	50 mg
Quantity options	100 mg 10mM/1mL 10 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	98.07
Formula	C15H15N5OS2
Citations	[1]Lv L, et al. Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation. Elife. 2020 Aug 17;9:e59994.
Smiles	O=C(NC1=NC=C(C)S1)CC2=CSC(NC3=NC(C)=CC=C3)=N2
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Available
Product Description	HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation. HQ461-mediated degradation of cyclin K impairs CDK12 function, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death[1].
StorageTemperature	-20°C, 3 years (Powder)
Shipping	Blue Ice
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	345.44
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 62.5 mg/mL (ultrasonic; warming; heat to 60°C)
Target	CDK; Molecular Glues
Manufacturers Target	CDK; Molecular Glues
Manufacturers Pathway	Cell Cycle/DNA Damage; PROTAC
Manufacturers Product type	Reference compound

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