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(Rac)-Cemsidomide

(Rac)-Cemsidomide

Item no.	HY-144841A-10mg
Manufacturer	MedChem Express
CASRN	2504233-68-3
Amount	10 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	97.34
Formula	C28H27N3O4
Citations	[1]David Proia et al. Advantageous therapies for disorders mediated by ikaros or aiolos. WO2022032132A1 (compound 5)<br>[2]James A. Henderson, et al. Abstract LB007: CFT7455: A novel, IKZF1/3 degrader that demonstrates potent tumor regression in IMiD-resistant multiple myeloma (MM) xenograft models. Cancer Res (2021) 81 (13_Supplement): LB007.
Smiles	O=C1N(C2C(NC(CC2)=O)=O)C3=CC=C(C4=CC=CC1=C43)CC5=CC=C(C=C5)CN6CCOCC6
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	(Rac)-CFT7455
Available
Product Description	(Rac)-Cemsidomide ((Rac)-CFT7455) is a zinc finger transcription factors Ikaros (IKZF1) and Aiolos (IKZF3) degrader, acting via the ubiquitin proteasome pathway, with a GI50 of 0.05 nM for NCIH929.1 cells. (Rac)-Cemsidomide is the racemic isomer of Cemsidomide (HY-144841A) which is a IKZF1/IKZF3 degrader with anticancer activity[1][2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	469.53
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer
Solubility	DMSO : 62.5 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturers Target	Others
Pathway	Others
Manufacturers Product type	Reference compound

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