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AKR1C3-IN-5

AKR1C3-IN-5

Item no.	HY-144749-1ea
Manufacturer	MedChem Express
CASRN	2839142-93-5
Amount	1 ea
Quantity options	100 mg 1 ea
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Formula	C34H44N2O7
Citations	[1]Rodrigues DM, et al. Synthesis, antitumor activity and in silico analyses of amino acid derivatives of artepillin C, drupanin and baccharin from green propolis. Bioorg Med Chem. 2021 Oct 1;47:116372.
Smiles	CC(OC1=CC=C(C=C1C/C=C(C)\C)/C=C/C(N[C@H](C(OCC2=CC=CC=C2)=O)CCCCNC(OC(C)(C)C)=O)=O)=O
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Available
Product Description	AKR1C3-IN-5 (Compound 6e) is a potent inhibitor of AKR1C3. AKR1C3 enzyme is overexpressed in hormone-dependent prostate and breast tumors. AKR1C3-IN-5 derived from drupanin, which exhibits half-maximal inhibitory concentration (IC50) of 9.6 ± 3 μM and selectivity index (SI) of 5.5 against MCF-7 cells[1].
Shipping	Room temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	592.72
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	10 mM in DMSO
Target	17β-HSD
Manufacturers Target	17β-HSD
Manufacturers Pathway	Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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