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Rivanicline

Rivanicline

Item no.	HY-13225A-1ea
Manufacturer	MedChem Express
CASRN	15585-43-0
Amount	1 ea
Quantity options	100 mg 10mM*1 mL 10mg 1 ea 50mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Formula	C10H14N2
Citations	[1]Bencherif M, et al. RJR-2403: a nicotinic agonist with CNS selectivity I. In vitro characterization. J Pharmacol Exp Ther. 1996 Dec;279(3):1413-21.<br/>[2]Lippiello PM, et al. RJR-2403: a nicotinic agonist with CNS selectivity II. In vivo characterization. J Pharmacol Exp Ther. 1996 Dec;279(3):1422-9.<br/>[3]Damaj MI, et al. Antinociceptive and pharmacological effects of metanicotine, a selective nicotinic agonist. J Pharmacol Exp Ther. 1999 Oct;291(1):390-8.
Smiles	CNCC/C=C/C1=CC=CN=C1
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	RJR-2403; (E)-Metanicotine
Available
Product Description	Rivanicline (RJR-2403; (E)-Metanicotine) is a neuronal nicotinic receptor (neuronal nicotinic receptor) agonist that is highly selective for the α4β2 subtype, Ki is 26 nM, which is more than 1000 times more inhibitory than α7 receptor[1].
Shipping	Room temperature
Manufacturers Applications	Neuroscience-Neuromodulation
MolecularWeight	162.23
Clinical Information	Phase 2
Manufacturers Research Area	Neurological Disease
Solubility	10 mM in DMSO
Target	nAChR
Manufacturers Target	nAChR
Manufacturers Pathway	Membrane Transporter/Ion Channel; Neuronal Signaling
Manufacturers Product type	Reference compound

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