Comparison

(±)11(12)-EET-d11 European Partner

Item no. HY-130494S-5mg
Manufacturer MedChem Express
CASRN 2699607-19-5
Amount 5 mg
Quantity options 10 ug (301.63 µM * 100 uL in Ethanol) 1 ea 1 mg 25 ug 5 mg
Category
Type Chemicals
Specific against other
Purity 98.0
Formula C20H21D11O3
Citations [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
[2] Luo XQ, et al. Epoxyeicosatrienoic acids inhibit the activation of NLRP3 inflammasome in murine macrophages. J Cell Physiol. 2020;235(12):9910-9921.
[3]Chacos N, et al. Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acid. Biochem Biophys Res Commun. 1982;104(3):916-922.
[4]Oliw EH, et al. Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates. J Biol Chem. 1982;257(7):3771-3781.
[5]Capdevila JH, et al. Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase. J Lipid Res. 2000;41(2):163-181.
[6]Wang Z, et al. Arachidonic acid inhibits basolateral K channels in the cortical collecting duct via cytochrome P-450 epoxygenase-dependent metabolic pathways. Am J Physiol Renal Physiol. 2008;294(6):F1441-F1447.
[7]Spector AA. Arachidonic acid cytochrome P450 epoxygenase pathway. J Lipid Res. 2009;50 Suppl(Suppl):S52-S56.
Smiles [2H]C([2H])(C([2H])(/C=C\C[C@@H]1[C@H](C/C=C\C/C=C\CCCC(O)=O)O1)[2H])C([2H])(C([2H])(C([2H])([2H])[2H])[2H])[2H]
ECLASS 10.1 32160000
ECLASS 11.0 32160000
UNSPSC 12000000
Alias (±)11,12-EET-d11
Shipping condition Cool pack
Available
Manufacturer - Type
Isotope-Labeled Compounds
Manufacturer - Targets
NOD-like Receptor (NLR)
Shipping Temperature
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Molecular Weight
331.53
Product Description
(±)11(12)-EET-d11 is the deuterium labeled (±)11(12)-EET. (±)11(12)-EET is a NLRP3 inflammasome inhibitor. (±)11(12)-EET can be used for the research of anti-inflammatory, angiogenic and cardioprotective[1][2][3][4][6].
Manufacturer - Research Area
Inflammation/Immunology; Cardiovascular Disease
Solubility
DMSO : 50 mg/mL (ultrasonic; warming)
Manufacturer - Pathway
Immunology/Inflammation
Clinical information
No Development Reported

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 5 mg
Available: In stock
available

Compare

Add to wishlist

Get an offer

Request delivery time

Ask a technical question

Submit a bulk request

Questions about this Product?
 
Close