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Nalfurafine

Nalfurafine

Item no.	HY-12745-1ea
Manufacturer	MedChem Express
CASRN	152657-84-6
Amount	1 ea
Quantity options	100 mg 10mg 1 ea 50mg 5mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Citations	[1].Kaski SW, et al. Preclinical Testing of Nalfurafine as an Opioid-sparing Adjuvant that Potentiates Analgesia by the Mu Opioid Receptor-targeting Agonist Morphine.J Pharmacol Exp Ther. 2019 Nov;371(2):487-499. <br> [2].Endoh T, et al. Potent antinociceptive effects of TRK-820, a novel kappa-opioid receptor agonist.Life Sci. 1999;65(16):1685-94.
Smiles	O[C@@]1(CC[C@@H](N(C)C(/C=C/C2=COC=C2)=O)[C@]3([H])OC4=C5O)[C@]63C4=C(C=C5)C[C@@]1([H])N(CC7CC7)CC6
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	TRK-820
Available
Product Description	Nalfurafine (TRK-820) is a potent selective and orally active G protein-biased kappa opioid receptor (KOR)-agonist with high translational potential. Nalfurafine (TRK-820) enhances the therapeutic potential of MOR-targeting analgesics, has the potential for uremic pruritis treatment.
StorageTemperature	Please store the product under the recommended conditions in the Certificate of Analysis.
Applications	Neuroscience-Neuromodulation
MolecularWeight	476.56
Research_Area	Neurological Disease
Target	Opioid Receptor
Pathway	GPCR/G Protein; Neuronal Signaling

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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