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Raphin1

Raphin1

Item no.	HY-123960-1ea
Manufacturer	MedChem Express
CASRN	2022961-17-5
Amount	1 ea
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Formula	C8H8Cl2N4
Citations	[1]Krzyzosiak A, et al. Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B. Cell. 2018 Aug 23;174(5):1216-1228.e19.
Smiles	N=C(N/N=C/C1=CC=CC(Cl)=C1Cl)N
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Available
Product Description	Raphin1 is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B). Raphin1 binds strongly to the R15B-PP1c holophosphatase (Kd=33 nM), and shows ~30-fold selective in binding R15B-PP1c over R15A-PP1c. Raphin1 crosses the blood-brain barrier, and reduces organismal and molecular deficits in a mouse model of a protein misfolding disease[1].
Shipping	Room temperature
Manufacturers Applications	Neuroscience-Neurodegeneration
MolecularWeight	231.08
Clinical_Information	No Development Reported
Manufacturers Research_Area	Neurological Disease
Solubility	DMSO : 125 mg/mL (ultrasonic)
Manufacturers Target	Phosphatase
Pathway	Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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