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4-Hydroperoxy Cyclophosphamide-d4

4-Hydroperoxy Cyclophosphamide-d4

Item no.	HY-117433S-5mg
Manufacturer	MedChem Express
CASRN	1246816-71-6
Amount	5 mg
Quantity options	10 mg 1 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	95.0
Formula	C7H11D4Cl2N2O4P
Dry ice	Yes
Citations	[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.<br/>[2]4-hydroperoxy-cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG
Smiles	N(CC(Cl)([2H])[2H])(CC(Cl)([2H])[2H])P1(=O)NC(OO)CCO1
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Available
Product Description	4-Hydroperoxy Cyclophosphamide-d4 is the deuterium labeled 4-Hydroperoxy cyclophosphamide. 4-Hydroperoxy cyclophosphamide is the active metabolite form of the proagent Cyclophosphamide. 4-Hydroperoxy cyclophosphamide crosslinks DNA and induces T cell apoptosis independent of death receptor activation, but activates mitochondrial death pathways through production of reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide has the potential for lymphomas and autoimmune disorders[1][2].
StorageTemperature	-80°C, stored under nitrogen
Shipping	Dry Ice
Manufacturers Applications	COVID-19-anti-virus
MolecularWeight	297.11
Clinical Information	No Development Reported
Manufacturers Research Area	Inflammation/Immunology
Solubility	10 mM in DMSO
Target	Apoptosis; DNA Alkylator/Crosslinker; Drug Metabolite; Reactive Oxygen Species
Manufacturers Target	Apoptosis; DNA Alkylator/Crosslinker; Drug Metabolite; Reactive Oxygen Species
Manufacturers Pathway	Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Manufacturers Product type	Isotope-Labeled Compounds

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