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Lotilaner

Lotilaner

Item no.	HY-116564-25mg
Manufacturer	MedChem Express
CASRN	1369852-71-0
Amount	25 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	99.84
Formula	C20H14Cl3F6N3O3S
Citations	[1]Lotilaner, et al. The novel isoxazoline ectoparasiticide lotilaner (Credelio™): a non-competitive antagonist specific to invertebrates γ-aminobutyric acid-gated chloride channels (GABACls). Parasit Vectors. 2017 Nov 1;10(1):530.
Smiles	O=C(NCC(NCC(F)(F)F)=O)C1=C(C=C(S1)C2=NO[C@](C3=CC(Cl)=C(C(Cl)=C3)Cl)(C2)C(F)(F)F)C
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Available
Product Description	Lotilaner is a parasiticide, acts as a potent non-competitive antagonist of insects GABACl receptors, with an IC50 of 23.84 nM for Drosophila melanogaster GABA receptor. No effect on a dog GABAA receptor[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	596.76
Clinical_Information	Launched
Manufacturers Research_Area	Infection
Solubility	DMSO : ≥ 100 mg/mL
Manufacturers Target	GABA Receptor; Parasite
Pathway	Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling
Manufacturers Product type	Reference compound

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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