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ONO-0300302

ONO-0300302

Item no.	HY-115450-50mg
Manufacturer	MedChem Express
CASRN	856689-51-5
Amount	50 mg
Quantity options	100 mg 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	99.43
Formula	C29H35NO5
Citations	[1]Terakado M, et al. Discovery of a Slow Tight Binding LPA1 Antagonist (ONO-0300302) for the Treatment of Benign Prostatic Hyperplasia. ACS Med Chem Lett. 2017 Nov 20;8(12):1281-1286.
Smiles	O=C(O)CCC1=CN(C[C@H](CC2CC3=C(C=CC=C3)C2)[C@@H](C4=CC(OC)=C(C)C(OC)=C4)O)C=C1
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Available
Product Description	ONO-0300302 is an orally active and potent LPA1 (lysophosphatidic acid receptor 1) antagonist, with an IC50 of 0.086 μM. ONO-0300302 is a slow tight binding inhibitor, and its binding affinity increases with time, with Kd of 0.34 nM (37 °C, 2 h). ONO-0300302 can be used for benign prostatic hyperplasia (BPH) research[1].
StorageTemperature	-20°C (Powder, protect from light)
Shipping	Blue Ice
Manufacturers Applications	Metabolism-protein/nucleotide metabolism
MolecularWeight	477.59
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer; Endocrinology
Solubility	DMSO : 220 mg/mL (ultrasonic)
Target	LPL Receptor
Manufacturers Target	LPL Receptor
Isoform	LPAR1
Manufacturers Pathway	GPCR/G Protein
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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