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PROTAC PARP1 degrader

PROTAC PARP1 degrader

Item no.	HY-114324-10mg
Manufacturer	MedChem Express
CASRN	2369022-68-2
Amount	10 mg
Quantity options	10 mg 1 ea 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	99.74
Citations	[1]Zhao Q, et al. Induction of apoptosis in MDA-MB-231 breast cancer cells by a PARP1-targeting PROTAC small molecule. Chem Commun (Camb). 2019 Jan 2;55(3):369-372.
Smiles	O=C(CN(C(N1C(C2=CC=C(OC)C=C2OC(C)C)=N[C@H](C3=CC=C(Cl)C=C3)[C@@H]1C4=CC=C(Cl)C=C4)=O)CC5)N5CC(NCCOCCOCCOCCOCCN6N=NC(C7=CC=C(N8N=C(C(C(N)=O)=CC=C9)C9=C8)C=C7)=C6)=O
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Available
Product Description	PROTAC PARP1 degrader is a PARP1 degrader based on MDM2 E3 ligand. It induces significant PARP1 cleavage and programmed cell death. PROTAC PARP1 degrader at 10 μM at 24 h inhibits MDA-MB-231 cell line with an IC50 of 6.12 μM.
StorageTemperature	-20°C (Powder, protect from light)
Shipping	Blue Ice
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	1145.09
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 100 mg/mL (ultrasonic)
Target	PARP; PROTACs
Manufacturers Target	PARP; PROTACs
Isoform	MDM2; PARP1
Manufacturers Pathway	Cell Cycle/DNA Damage; Epigenetics; PROTAC
Manufacturers Product type	Reference compound

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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