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AZ10606120 (dihydrochloride)

AZ10606120 (dihydrochloride)

Item no.	HY-108669-10mg
Manufacturer	MedChem Express
CASRN	607378-18-7
Amount	10 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	99.38
Formula	C25H36Cl2N4O2
Citations	[1]Kan LK, et al. P2X7 receptor antagonism by AZ10606120 significantly reduced in vitro tumour growth in human glioblastoma. Sci Rep. 2023 May 24;13(1):8435. <br>[2]Giannuzzo A, et al. The P2X7 receptor regulates cell survival, migration and invasion of pancreatic ductal adenocarcinoma cells. Mol Cancer. 2015 Nov 25;14:203.<br>[3]Clapp C, et al. Pharmacological blockade of the P2X7 receptor reverses retinal damage in a rat model of type 1 diabetes. Acta Diabetol. 2019 Sep;56(9):1031-1036. <br>[4]Csölle C, et al. Neurochemical Changes in the Mouse Hippocampus Underlying the Antidepressant Effect of Genetic Deletion of P2X7 Receptors. PLoS One. 2013 Jun 21;8(6):e66547.<br>[5]Pegoraro A, et al. Differential sensitivity of acute myeloid leukemia cells to daunorubicin depends on P2X7A versus P2X7B receptor expression. Cell Death Dis. 2020 Oct 18;11(10):876. <br>[6]Allsopp RC, et al. Unique residues in the ATP gated human P2X7 receptor define a novel allosteric binding pocket for the selective antagonist AZ10606120. Sci Rep. 2017 Apr 7;7(1):725.
Smiles	O=C(NC1=C2C=CC(NCCNCCO)=NC2=CC=C1)CC3(C4)CC5CC4CC(C5)C3.[H]Cl.[H]Cl
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Available
Product Description	AZ10606120 dihydrochloride is a selective, high affinity antagonist for P2X7 receptor (P2X7R) at human and rat with an IC50 of about 10 nM. AZ10606120 dihydrochloride is little or no effect at other P2XR subtypes. AZ10606120 dihydrochloride has anti-depressant effects and reduces tumour growth[1].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	495.48
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer; Neurological Disease
Solubility	DMSO : 8.33 mg/mL (ultrasonic)\|H2O : 2 mg/mL (ultrasonic)
Manufacturers Target	P2X Receptor
Isoform	P2X7 Receptor
Pathway	Membrane Transporter/Ion Channel
Manufacturers Product type	Reference compound

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