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L-Buthionine-(S,R)-sulfoximine

L-Buthionine-(S,R)-sulfoximine

Item no.	HY-106376A-100mg
Manufacturer	MedChem Express
CASRN	83730-53-4
Amount	100 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	99.0
Formula	C8H18N2O3S
Citations	[1]Satoru Nishizawa, et al. Low tumor glutathione level as a sensitivity marker for glutamate-cysteine ligase inhibitors. Oncol Lett. 2018 Jun;15(6):8735-8743.<br>[2]Fruehauf JP, et al. Selective and synergistic activity of L-S,R-buthionine sulfoximine on malignant melanoma is accompanied by decreased expression of glutathione-S-transferase. Pigment Cell Res. 1997 Aug;10(4):236-49.<br>[3]Reliene R, et al. Glutathione depletion by buthionine sulfoximine induces DNA deletions in mice. Carcinogenesis. 2006 Feb;27(2):240-4.
Smiles	N[C@H](C(O)=O)CCS(CCCC)(=O)=N
ECLASS 5.1	32160000
ECLASS 6.1	32160000
ECLASS 8.0	32160000
ECLASS 9.0	32160000
ECLASS 10.0.1	32160000
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	L-Buthionine sulfoximine; L-BSO
Available
Product Description	L-Buthionine-(S, R)-sulfoximine is a cell-permeable, potent, fast acting and irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. The IC50 value of L-Buthionine-(S, R)-sulfoximine on melanoma, breast and ovarian tumor specimens are 1.9 μM, 8.6 μM, and 29 μM, respectively.
StorageTemperature	-20°C (Powder, sealed storage, away from moisture)
Shipping	Blue Ice
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	222.31
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer
Solubility	DMSO : < 1 mg/mL (ultrasonic)\|H2O : 18.33 mg/mL (ultrasonic)
Manufacturers Target	Ferroptosis
Pathway	Apoptosis
Manufacturers Product type	Reference compound

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 mg

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