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Tezacitabine

Tezacitabine

Item no.	HY-106014-5mg
Manufacturer	MedChem Express
CASRN	130306-02-4
Amount	5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	99.35
Formula	C10H12FN3O4
Dry ice	Yes
Citations	[1]Janusz S Skierski, et al. Tezacitabine Blocks Tumor Cells in G1 and S Phases of the Cell Cycle and Induces Apoptotic Cell Death. Acta Pol Pharm. May-Jun 2005;62(3):195-205.<br>[2]Pietro Taverna, et al. Tezacitabine Enhances the DNA-directed Effects of Fluoropyrimidines in Human Colon Cancer Cells and Tumor Xenografts. Biochem Pharmacol. 2007 Jan 1;73(1):44-55.
Smiles	F/C=C1[C@H](N2C(N=C(N)C=C2)=O)O[C@H](CO)[C@H]/1O
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Available
Product Description	Tezacitabine is a cytostatic and cytotoxic antimetabolite and a nucleoside analogue. Tezacitabine irreversibly inhibits the ribonucleotide reductase and interferes with DNA replication and repair. Tezacitabine effectively induces cells apoptotic. Tezacitabine has the potential for leukemias and solid tumors (carcinomas) treatment[1][2].
StorageTemperature	-80°C
Shipping	Dry Ice
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	257.22
Clinical_Information	Phase 2
Manufacturers Research_Area	Cancer
Solubility	DMSO : 200 mg/mL (ultrasonic)\|H2O : 200 mg/mL (ultrasonic)
Manufacturers Target	Apoptosis; DNA/RNA Synthesis; Nucleoside Antimetabolite/Analog
Pathway	Apoptosis; Cell Cycle/DNA Damage
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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