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Panobinostat-d4

Panobinostat-d4

Item no.	HY-10224S-5mg
Manufacturer	MedChem Express
CASRN	1185237-51-7
Amount	5mg
Quantity options	1ea 1mg 5mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Formula	C21H19D4N3O2
Citations	[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. <br/>[2]Scuto A, et al. The novel histone deacetylase inhibitor, LBH589, induces expression of DNA damage response genes and apoptosis in Ph- acute lymphoblastic leukemia cells. Blood. 2008 May 15;111(10):5093-100.<br/>[3]Crisanti MC, et al. The HDAC inhibitor panobinostat (LBH589) inhibits mesothelioma and lung cancer cells in vitro and in vivo with particular efficacy for small cell lung cancer. Mol Cancer Ther. 2009 Aug;8(8):2221-31.<br/>[4]Ocio EM, et al. In vitro and in vivo rationale for the triple combination of panobinostat (LBH589) and dexamethasone with either bortezomib or lenalidomide in multiple myeloma. Haematologica. 2010 May;95(5):794-803.<br/>[5]Banerjee NS, et al. Vorinostat, a pan-HDAC inhibitor, abrogates productive HPV-18 DNA amplification. Proc Natl Acad Sci U S A. 2018 Nov 20;115(47):E11138-E11147.<br/>[6]Barton K, et al. Broad activation of latent HIV-1 in vivo. Nat Commun. 2016;7:12731. Published 2016 Sep 8.
Smiles	O=C(NO)/C=C/C1=CC=C(CNCCC2=C(C)NC3=C2C([2H])=C([2H])C([2H])=C3[2H])C=C1
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	LBH589-d4; NVP-LBH589-d4
Available
Product Description	Panobinostat-d4 is the deuterium labeled Panobinostat. Panobinostat (LBH589; NVP-LBH589) is a potent and orally active non-selective HDAC inhibitor, and has antineoplastic activities[1][2]. Panobinostat induces HIV-1 virus production even at low concentration range 8-31 nM, stimulates HIV-1 expression in latently infected cells[4]. Panobinostat induces cell apoptosis and autophagy. Panobinostat can be used for the study of refractory or relapsed multiple myeloma[3].
Shipping	Room temperature
MolecularWeight	353.45
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	10 mM in DMSO
Target	Apoptosis; Autophagy; HDAC; HIV
Manufacturers Target	Apoptosis; Autophagy; HDAC; HIV
Manufacturers Pathway	Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics
Manufacturers Product type	Isotope-Labeled Compounds

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