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Pazopanib-d6

Pazopanib-d6

Item no.	HY-10208S-1mg
Manufacturer	MedChem Express
CASRN	1219592-01-4
Amount	1 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	98.0
Formula	C21H17D6N7O2S
Citations	[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. <br>[2]Harris PA, et al. Discovery of 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor. J Med Chem. 2008, 51(15), 4632-4640.<br>[3]Thakur A, et al. Pazopanib, a multitargeted tyrosine kinase inhibitor, reduces diabetic retinal vascular leukostasis and leakage. Microvasc Res. 2011 Nov;82(3):346-50.
Smiles	CC1=CC=C(NC2=NC=CC(N(C3=CC4=NN(C(C)=C4C=C3)C([2H])([2H])[2H])C([2H])([2H])[2H])=N2)C=C1S(N)(=O)=O
ECLASS 5.1	32160000
ECLASS 6.1	32160000
ECLASS 8.0	32160000
ECLASS 9.0	32160000
ECLASS 10.0.1	32160000
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	GW786034-d6
Available
Product Description	Pazopanib-d6 is the deuterium labeled Pazopanib. Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with IC50s of 10, 30, 47, 84, 74, 140 and 146 nM, respectively.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
MolecularWeight	443.55
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer
Solubility	10 mM in DMSO
Pathway	Autophagy; Others; Protein Tyrosine Kinase/RTK
Manufacturers Product type	Isotope-Labeled Compounds

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