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Caspases Group II, Activ Human

Caspases Group II, Activ Human

Manufacturer	Raybiotech
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins
Specific against	other
Amount	3 x 25 units
Item no.	268-11492-1
eClass 6.1	34160400
eClass 9.0	42020190
Available
Short Description	Group II contains active caspase-2/-3/-7.
Introduction	Caspase family consists of more than 10 members. Based on their extended substrate specificities, these enzymes were divided into three major groups: Group I (contains caspase-1, -4, -5), Group II (contains caspase-2, -3, -7), and Group III (contains caspase-6, -8, -9, -10). Evidences have suggested that Group I caspases are involved primarily in the production of inflammatory cytokines, while group II and III enzymes function in apoptosis as effectors and upstream activators, respectively. The group caspases were expressed in E. coli and routinely tested for their ability to enzymatically cleave the substrate VDVAD-pNA (for caspase-2) and DEVD-pNA (for caspase-3 & -7).
Gene Symbol	CASP2 CASP3 CASP7
UniProt Accession Number	CASP2- P42575 CASP3- P42574 CASP7- P55210
NCBI Gene ID	CASP2- 835 CASP3- 836 CASP7- 840
Country of Animal Origin	USA
Unit Definition	One unit of the active recombinant caspase-2, -3, -7 is the enzyme activity that cleaves 1 nmol of the caspase substrate VDVAD-pNA (for caspase-2) and DEVD-pNA (for caspase-3 & -7), respectively, per hour at 37° C in a reaction solution containing 50 mM Hepes, pH 7.2, 50 mM NaCl, 0.1% Chaps, 10 mM EDTA, 5% Glycerol, and 10 mM DTT.
Protein Type	Recombinant Protein
Shipping	gel pack
Reconstitution	Reconstitute to 1 unit per µ l in PBS.
Storage/stability	The protein may be stored for 12 months at -70° C

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