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Caspases Group II, Activ Human

Caspases Group II, Activ Human

Item no.	268-11492-1
Manufacturer	Raybiotech
Amount	3 x 25 units
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins
Specific against	other
Host	Hamster - Armenian
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Shipping condition	Cool pack
Available
Manufacturer - Category	Recombinant Protein
Shipping Temperature	gel pack
Storage Conditions	The protein may be stored for 12 months at -70° C
Description	Group II contains active caspase-2/-3/-7.
Gene Symbols	CASP2 CASP3 CASP7
Reconstitution	Reconstitute to 1 unit per µ l in PBS.
Introduction	Caspase family consists of more than 10 members. Based on their extended substrate specificities, these enzymes were divided into three major groups: Group I (contains caspase-1, -4, -5), Group II (contains caspase-2, -3, -7), and Group III (contains caspase-6, -8, -9, -10). Evidences have suggested that Group I caspases are involved primarily in the production of inflammatory cytokines, while group II and III enzymes function in apoptosis as effectors and upstream activators, respectively. The group caspases were expressed in E. coli and routinely tested for their ability to enzymatically cleave the substrate VDVAD-pNA (for caspase-2) and DEVD-pNA (for caspase-3 & -7).
Unit Definition	One unit of the active recombinant caspase-2, -3, -7 is the enzyme activity that cleaves 1 nmol of the caspase substrate VDVAD-pNA (for caspase-2) and DEVD-pNA (for caspase-3 & -7), respectively, per hour at 37° C in a reaction solution containing 50 mM Hepes, pH 7.2, 50 mM NaCl, 0.1% Chaps, 10 mM EDTA, 5% Glycerol, and 10 mM DTT.
Country of Animal Origin	USA

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