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Human Apoptosis Array C1

Human Apoptosis Array C1

Item no.	AAH-APO-1-8
Manufacturer	Raybiotech
Amount	8 Sample Kit
Quantity options	2 Sample Kit 4 Sample Kit 8 Sample Kit
Category	Oncology Neuroscience Neural Lineage Markers Neuroinflammation Metabolism Diabetes Cholesterol & Lipid Metabolism Neural Mitochondrial Function Molecular Targets for Neuroscience Targets for Rodent Neurosciences Aging & Neurological Disorders Protein Aggregation, Clearance & Misfolding By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Cell Biology Obesity Cell Status Apoptosis Autophagy Senescence Cardiovascular Research Ischemia & Reperfusion Injury Enzymes Fatty Acid Synthesis Arrays By Organ Lung Cancer Skin Cancer Bladder Cancer Colorectal Cancer Breast Cancer Testicular & Prostate Cancer Brain Cancer Neuronal Cell Markers Antibody Arrays
Type	Array
Specific against	Human
Host	Hamster - Armenian
Citations	1. Spadavecchia S, Gonzalez-Lopez OD, Kyla Driscoll Carroll KD, Diana Palmeri D, Lukac DM. Convergence of KSHV Reactivation with EBV latency and cellular growth mediated by the Notch signaling pathway in co-infected cells. J Virol. 2010:84(20):10488–15000. 2. Malla R., et al. Downregulation of uPAR and Cathepsin B Induces Apoptosis via Regulation of Bcl-2 and Bax and Inhibition of the PI3K/Akt Pathway in Gliomas. PLOS One. Published: October 29, 2010 DOI: 10.1371/journal.pone.0013731 3. Rahabi-Layachi H., et al. You have full text access to this content Distinct effects of inorganic phosphate on cell cycle and apoptosis in human vascular smooth muscle cells. J of Cell Phys. Accepted manuscript online: 27 JUN 2014. \| DOI: 10.1002/jcp.24715 4. Wu J., et al. Blocking the bFGF/STAT3 interaction through specific signaling pathways induces apoptosis in glioblastoma cells. J Neurooncol publihsed online July 2014. DOI 10.1007/s11060-014-1529-8 5. Lattuada D., et al. Proapoptotic Activity of a Monomeric Smac Mimetic on Human Fibroblast-Like Synoviocytes from Patients with Rheumatoid Arthritis. Inflammation, Sept 2014, epub ahead of print. DOI: 10.1007/s10753-014-0012-1 6. Paydar, M., Kamalidehghan, B. et al. evaluation of cytotoxic and chemotherapeutic properties of boldine in breast cancer using in vitro and in vivo models. Drug Design, Development and Therapy, Volume 2014:8 Pages 719 - 733. June 2014 7. Karimian H., et al. Ferulago angulata activates intrinsic pathway of apoptosis in MCF-7 cells associated with G1 cell cycle arrest via involvement of p21/p27. Drug Design, Development and Therapy, Sept 2014, epub ahead of print.http://dx.doi.org/10.2147/DDDT.S68818
ECLASS 10.1	32161000
ECLASS 11.0	32161000
UNSPSC	41116126
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Available
Number of Targets Detected	43
Species Detected	Human
Compatible Sample Types	Cell Culture Supernatants Cell Lysates Plasma Serum Tissue Lysates
Design Principle	Sandwich-based
Method of Detection	Chemiluminescence
Quantitative/Semi-Quantitative	Semi-Quantitative
Solid Support	Membrane
Gene Symbols	BAD \| BAX \| BCL2 \| BCL2L11 \| BCL2L2 \| BID \| BIRC3 \| BIRC5 \| BIRC7 \| CASP3\| CASP8 \| CD40 \| CD40LG \| CDKN1A \| CYCS \| DIABLO \| FAS \| FASLG \| HSPA14 \| HSPA4 \| HSPB1 \| HTRA2 \| IGF1 \| IGF1R \| IGF2 \| IGFBP1 \| IGFBP2 \| IGFBP3 \| IGFBP4 \| IGFBP5 \| IGFBP6 \| LTA \| SSSCA1 \| TNF \| TNFRSF10A \| TNFRSF10B \| TNFRSF10C \| TNFRSF10D \| TNFRSF1A \| TNFRSF1B \| TNFRSF21 \| TP53 \| XIAP
Application Information	Multiplexed Protein Detection Detection of Relative Protein Expression Detecting Patterns of Cytokine Expression Biomarker/ Key Factor Screening Identifying Key Factors Confirming a Biological Process
Kit Components	Human Apoptosis Antibody Array C1 Membranes Blocking Buffer Wash Buffer 1 Wash Buffer 2 Biotinylated Detection Antibody Cocktail Streptavidin- Conjugated H R P Detection Buffer C Detection Buffer D Lysis Buffer Protease Inhibitor Cocktail8- Well Incubation Tray Plastic Sheets Array Templates Manual
Other Materials Required	Pipettors, pipet tips and other common lab consumables Orbital shaker or oscillating rocker Tissue Paper, blotting paper or chromatography paper Adhesive tape or Saran Wrap Distilled or de-ionized water A chemiluminescent blot documentation system (such as U V P's Chemi Doc- It® or Epi Chem I I Benchtop Darkroom or G E's Image Quant™ L A S 4000 or Amersham Imagers 600 and 680), X-ray Film and a suitable film processor, or another chemiluminescent detection system.
Protocol Outline	Block membranes Incubate with Sample Incubate with Biotinylated Detection Antibody Cocktail Incubate with H R P- Conjugated Streptavidin Incubate with Detection Buffers Image with chemiluminescent imaging system Perform densitometry and analysis
Product Features	Easy to use No specialized equipment needed Compatible with nearly any liquid sample Proven technology (many publications) Highly sensitive (pg/ml) Sandwich ELISA specificity Higher density than ELISA, Western blot or bead-based multiplex
Pathway	Akt SignalingIGF Signalingp53 Signaling

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.