Anti-ACE2 (N-term) Antibody

Immunohistology - Paraffin, Western Blotting

Phosphate buffered saline

IgG concentration 1.0 mg/ml

This product is specific for human Angiotensin-converting enzyme 2 (ACE2). ACE2 is a carboxypeptidase which is expressed in a range of tissues including heart, kidney, testis and the gastrointestinal system. ACE2 is a homologue of ACE (Angiotensin-converting enzyme 1), although it has a distinct catalytic activity. ACE2 catalyzes the cleavage of active angiotensin II into angiotensin 1-7, which may counteract the effects of ACE by increasing vasodilatation.A recent discovery is that ACE2 serves as the cellular entry point for the severe acute respiratory syndrome (SARS) virus, functioning as a receptor for the SARS Spike protein.

Antisera to human ACE2 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.

Purified IgG - liquid