Anti-RUNX1/AML1 Rabbit pAb

Primary Antibodies

RUNX1/AML1

Store at -20°C. Avoid freeze/thaw cycles.

RUNX1/AML1, also known as CBFA2 or PEBP2αB, is a member of the core binding factor (CBF) family of transcription factors. It is required for normal development of all hematopoietic lineages. RUNX1/AML1 forms a heterodimeric DNA binding complex with its partner protein CBFβ and regulates the expression of cellular genes by binding to promoter and enhancer elements. RUNX1/AML1 is commonly translocated in hematopoietic cancers: chromosomal translocations include t(8; 21) AML1-ETO, t(12; 21) TEL-AML, and t(8; 21) AML-M2. Phosphorylation of RUNX1/AML1 on several potential serine and threonine sites, including Ser249, is thought to occur in an Erk-dependent manner.

PBS, Glycerol, BSA

Polyclonal

RUNX1/AML1, also known as CBFA2 or PEBP2αB, is a member of the core binding factor (CBF) family of transcription factors. It is required for normal development of all hematopoietic lineages. RUNX1/AML1 forms a heterodimeric DNA binding complex with its partner protein CBFβ and regulates the expression of cellular genes by binding to promoter and enhancer elements. RUNX1/AML1 is commonly translocated in hematopoietic cancers: chromosomal translocations include t(8; 21) AML1-ETO, t(12; 21) TEL-AML, and t(8; 21) AML-M2. Phosphorylation of RUNX1/AML1 on several potential serine and threonine sites, including Ser249, is thought to occur in an Erk-dependent manner.