Item no. |
PTM-6754 |
Manufacturer |
PTM Biolabs
|
Amount |
100 ul |
Format |
Lyophilized powder |
Applications |
WB, IHC-P |
Clone |
JMMR-3479 |
Specific against |
Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus) |
Host |
Rabbit |
Isotype |
IgG Kappa |
Conjugate/Tag |
Unconjugated |
Alias |
Homeobox protein Nkx-2.1, Homeobox protein NK-2 homolog A, Thyroid nuclear factor 1, NKX2-1, NKX2A, TTF-1, T/EBP, Thyroid Transcription Factor-1 |
Shipping condition |
Room temperature |
Available |
|
Manufacturer - Type |
Primary Antibodies |
Manufacturer - Category |
Uncategorized |
Manufacturer - Targets |
TTF1 |
Shipping Temperature |
Ambient temperature |
Storage Conditions |
Store at -20°C. Avoid freeze/thaw cycles. |
Manufacturer - Research Area |
Epigenetics |
Product description |
Homeobox protein Nkx-2.1 (NKX2-1), also named Thyroid nuclear factor 1, Thyroid transcription factor 1(TTF1). It is a transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. It may play a role in lung development and surfactant homeostasis. Defects in NKX2-1 are the cause of benign hereditary chorea (BHC), choreoathetosis, hypothyroidism, and neonatal respiratory distress (CHNRD). |
Purification Method |
Protein A purified |
Constituents |
PBS, Glycerol, BSA |
PTM |
Unmodified |
Clonality |
Recombinant Monoclonal |
Stability |
Stable for 12 months from date of receipt/reconstitution. |
Background |
Homeobox protein Nkx-2.1 (NKX2-1), also named Thyroid nuclear factor 1, Thyroid transcription factor 1(TTF1). It is a transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. It may play a role in lung development and surfactant homeostasis. Defects in NKX2-1 are the cause of benign hereditary chorea (BHC), choreoathetosis, hypothyroidism, and neonatal respiratory distress (CHNRD). |
Cellular Localization |
Nucleus |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.